STUDY OF THE RV1417 AND RV2617C MEMBRANE PROTEINS AND THEIR INTERACTIONS WITH NICOTINE DERIVATIVES AS POTENTIAL INHIBITORS OF ERP VIRULENCE-ASSOCIATED FACTOR IN MYCOBACTERIUM TUBERCULOSIS: AN IN SILICO APPROACH

The increasing emergence of Mycobacterium tuberculosis (Mtb) strains resistant to traditional anti-tuberculosis drugs has alarmed health services worldwide.The search for new therapeutic targets and effective drugs that counteract the virulence and multiplication of Mtb represents a challenge for the scientific community.Several studies have consid

Abstract Authors of a matched cohort study claimed the NHS Health Check programme reduced total mortality 23% and liver cirrhosis incidence 44%.Such impressive results require critical scrutiny, especially as the intervention targets a large, predominantly healthy population, and as it has harms and costs.Eleven high-quality randomised trials conta

Abstract.Musculoskeletal (MSK) education is underemphasized in medical school curricula, which can lead to decreased confidence in treating MSK conditions and suboptimal performance on orthopaedic surgery elective rotations read more or subinternships.Given the low amount of formalized education in MSK medicine, students aiming to learn about ortho

Abstract Background The physiological function of eukaryotic DNA occurs in the context invertatop squeeze bottle of nucleosomal arrays that can expose or obscure defined segments of the genome.Certain DNA sequences are capable of strongly positioning a nucleosome in vitro, suggesting the possibility that favorable intrinsic signals might reproducib